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Ficha CTI Vitae
PAREDES OLORTEGUI MARIBEL

Fecha de última actualización: 20-10-2022
 
Código de Registro:   P0045671
Ver:   Ficha Renacyt


Scopus Author Identifier: 55584268400
Web of Science ResearcherID: null
Fecha:  07/01/2019

Datos Personales

    Fuente
Apellidos : PAREDES OLORTEGUI
Nombres: MARIBEL
Género: FEMENINO
Nacionalidad: PERÚ

Datos Actuales

Pagina web personal: http://
Pais de residencia: Perú

Experiencia Laboral

Institución Cargo Descripción del cargo Cargo en I+d+i Fecha Inicio Fecha Fin
ASOCIACION BENEFICA PRISMA JEFA DE PROYECTOS Otros cargos relacionados a (I+D+i) Febrero 2000 A la actualidad

Experiencia Laboral como Docente

Institución Tipo Institución Tipo Docente Descripción del cargo Fecha Inicio Fecha Fin

Experiencia como Asesor de Tesis

Universidad Tesis Tesista(s) Repositorio Fecha Aceptación de Tesis

Experiencia como evaluador y/o formulador de proyectos

Tipo de experiencia Ańo Tipo de proyecto Entidad financiadora Nombre del concurso Metodología de evaluación Monto proyecto (USD)

Formación Académica (Fuente: SUNEDU)

Grado Título Centro de Estudios País de Estudios Fuente
LICENCIADO / TÍTULO BIOLOGO UNIVERSIDAD NACIONAL DE LA AMAZONIA PERUANA PERÚ
BACHILLER BACHILLER EN CIENCIAS BIOLOGICAS UNIVERSIDAD NACIONAL DE LA AMAZONIA PERUANA PERÚ

Formación Académica (Fuente: Manual)

Grado Título Centro de Estudios País de Estudios Fecha de inicio Fecha fin Fuente

Estudios Técnicos

Centro de estudios Carrera Fecha de Inicio Fecha de fin

Estudios académicos y/o técnicos superiores en curso

Centro de estudios Carrera Tipo de estudios Fecha de inicio

Formación Complementaria

Centro de estudios Capacitación complementaria Frecuencia Cantidad País de estudio Fecha de inicio Fecha fin

Idiomas

Idioma Lectura Conversación Escritura Forma de aprendizaje Lengua Materna
INGLES AVANZADO INTERMEDIO INTERMEDIO Estudio Instituto NO
PORTUGUES INTERMEDIO INTERMEDIO INTERMEDIO Estudio Instituto NO

Línea de investigación

Área Sub área Disciplina Temática Ambiental Temática Médica y de la Salud
Ciencias Médicas y de la Salud Biotecnología en Salud Biotecnología relacionada con la salud Malnutrición y anemia (incluye obesidad)
Ciencias Médicas y de la Salud Ciencias de la Salud Enfermedades infecciosas Infecciones Intestinales
Ciencias Médicas y de la Salud Ciencias de la Salud Enfermedades infecciosas Tuberculosis
Ciencias Médicas y de la Salud Ciencias de la Salud Enfermedades infecciosas Metaxénicas y zoonóticas

Producción científica

Tipo Producción Título Autor Año de Producción DOI Revista Fuente Cuartil de ScimagoJR o JCR*
Artículo en revista científica Associations Between Eight Earth Observation-Derived Climate Variables and Enteropathogen Infection: An Independent Participant Data Meta-Analysis of Surveillance Studies With Broad Spectrum Nucleic Acid Diagnostics Colston J.M. 2022 10.1029/2021GH000452 GeoHealth Q1
Artículo en revista científica Resistance to single dose albendazole and reinfection with intestinal helminths among children ages 2 to 11 years from the Peruvian Amazon region: a study protocol Curico G. 2022 10.1186/s12879-022-07494-0 BMC Infectious Diseases Q2
Artículo en revista científica Micronutrient intake and the probability of nutrient adequacy among children 9-24 months of age: Results from the MAL-ED birth cohort study Antiporta D.A. 2021 10.1017/S1368980020000877 Public Health Nutrition Q1
Artículo en revista científica La Niña weather impacts dietary patterns and dietary diversity among children in the Peruvian Amazon Ambikapathi R. 2021 10.1017/S1368980020003705 Public Health Nutrition Q1
Artículo en revista científica Homotypic and Heterotypic Protection and Risk of Reinfection following Natural Norovirus Infection in a Highly Endemic Setting Chhabra P. 2021 10.1093/cid/ciaa019 Clinical Infectious Diseases Q1
Artículo en revista científica Characteristics associated with the transition to partial breastfeeding prior to 6 months of age: Data from seven sites in a birth cohort study Richard S.A. 2021 10.1111/mcn.13166 Maternal and Child Nutrition Q1
Artículo en revista científica Genomic Characterization of Campylobacter jejuni Adapted to the Guinea Pig (Cavia porcellus) Host Parker C.T. 2021 10.3389/fcimb.2021.607747 Frontiers in Cellular and Infection Microbiology Q1
Artículo en revista científica Associations among household animal ownership, infrastructure, and hygiene characteristics with source attribution of household fecal contamination in Peri-urban communities of Iquitos, Peru Schiaffino F. 2021 10.4269/AJTMH.20-0810 American Journal of Tropical Medicine and Hygiene Q1
Artículo en revista científica Validation of microbial source tracking markers for the attribution of fecal contamination in indoor-household environments of the Peruvian Amazon Schiaffino F. 2020 10.1016/j.scitotenv.2020.140531 Science of the Total Environment Q1
Artículo en revista científica Diarrhea as a potential cause and consequence of reduced gut microbial diversity among undernourished children in peru Rouhani S. 2020 10.1093/cid/ciz905 Clinical Infectious Diseases Q1
Artículo en revista científica Gut microbiota features associated with campylobacter burden and postnatal linear growth deficits in a peruvian birth cohort Rouhani S. 2020 10.1093/cid/ciz906 Clinical Infectious Diseases Q1
Artículo en revista científica Metabolic maturation in the first 2 years of life in resource-constrained settings and its association with postnatal growths Giallourou N. 2020 10.1126/sciadv.aay5969 Science advances Q1
Artículo en revista científica Optimisation, validation and field applicability of a 13C-sucrose breath test to assess intestinal function in environmental enteropathy among children in resource poor settings: Study protocol for a prospective study in Bangladesh, India, Kenya, Jam Lee G.O. 2020 10.1136/bmjopen-2019-035841 BMJ Open Q1
Artículo en revista científica Genomic epidemiology of campylobacter jejuni associated with asymptomatic pediatric infection in the peruvian amazon Pascoe B. 2020 10.1371/journal.pntd.0008533 PLoS Neglected Tropical Diseases Q1
Artículo en revista científica Pathogen-specific impacts of the 2011–2012 la Niña-associated floods on enteric infections in the MAL-ED Peru Cohort: A comparative interrupted time series analysis Colston J. 2020 10.3390/ijerph17020487 International Journal of Environmental Research and Public Health Q2
Artículo en revista científica Associations between household-level exposures and all-cause diarrhea and pathogen-specific enteric infections in children enrolled in five sentinel surveillance studies Colston J.M. 2020 10.3390/ijerph17218078 International Journal of Environmental Research and Public Health Q2
Artículo en revista científica Campylobacter jejuni capsule types in a Peruvian birth cohort and associations with diarrhoeal disease severity Neitenbach B. 2019 10.1017/S0950268818002960 Epidemiology and Infection Q2
Artículo en revista científica Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru Schiaffino F. 2019 10.1055/s-0038-1676614 American Journal of Perinatology Q1
Article Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru Schiaffino, Francesca 2019 10.1055/s-0038-1676614 AMERICAN JOURNAL OF PERINATOLOGY Q3
Artículo en revista científica Intestinal permeability and inflammation mediate the association between nutrient density of complementary foods and biochemical measures of micronutrient status in young children: Results from the MAL-ED study McCormick B.J.J. 2019 10.1093/ajcn/nqz151 American Journal of Clinical Nutrition Q1
Artículo en revista científica Minimally invasive saliva testing to monitor norovirus infection in community settings Pisanic N. 2019 10.1093/infdis/jiy638 Journal of Infectious Diseases Q1
Artículo en revista científica Effects of Child and Maternal Histo-Blood Group Antigen Status on Symptomatic and Asymptomatic Enteric Infections in Early Childhood Colston J.M. 2019 10.1093/infdis/jiz072 Journal of Infectious Diseases Q1
Artículo en revista científica Safety of Lactobacillus Reuteri DSM 17938 in Healthy Children 2-5 Years of Age Kosek M.N. 2019 10.1097/INF.0000000000002267 Pediatric Infectious Disease Journal Q1
Article SAFETY OF LACTOBACILLUS REUTERI DSM 17938 IN HEALTHY CHILDREN 2-5 YEARS OF AGE Kosek, Margaret N. 2019 10.1097/INF.0000000000002267 PEDIATRIC INFECTIOUS DISEASE JOURNAL Q2
Artículo en revista científica Antibiotic resistance of Campylobacter species in a pediatric cohort study Schiaffino F. 2019 10.1128/AAC.01911-18 Antimicrobial Agents and Chemotherapy Q1
Article Antibiotic Resistance of Campylobacter Species in a Pediatric Cohort Study Schiaffino, Francesca 2019 10.1128/AAC.01911-18 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Q1
Artículo en revista científica Penalized regression models to select biomarkers of environmental enteric dysfunction associated with linear growth acquisition in a Peruvian birth cohort Colston J.M. 2019 10.1371/journal.pntd.0007851 PLoS Neglected Tropical Diseases Q1
Artículo en revista científica Food purchase patterns indicative of household food access insecurity, children’s dietary diversity and intake, and nutritional status using a newly developed and validated tool in the Peruvian Amazon Ambikapathi R. 2018 10.1007/s12571-018-0815-2 Food Security Q1
Article Social connectedness is associated with food security among peri-urban Peruvian Amazonian communities Lee, Gwenyth O. 2018 10.1016/j.ssmph.2018.02.004 S/C***
Artículo en revista científica Social connectedness is associated with food security among peri-urban Peruvian Amazonian communities Lee G.O. 2018 10.1016/j.ssmph.2018.02.004 SSM - Population Health Q1
Artículo en revista científica Seasonality and within-subject clustering of rotavirus infections in an eight-site birth cohort study Colston J. 2018 10.1017/S0950268818000304 Epidemiology and Infection Q2
Article Seasonality and within-subject clustering of rotavirus infections in an eight-site birth cohort study Colston, J. M. 2018 10.1017/S0950268818000304 EPIDEMIOLOGY AND INFECTION Q2
Artículo en revista científica Near-complete genome sequences of several new norovirus genogroup II genotypes Chhabra P. 2018 10.1128/genomeA.00007-18 Genome Announcements Q3
Article The other Campylobacters: Not innocent bystanders in endemic diarrhea and dysentery in children in low-income settings Francois, Ruthly 2018 10.1371/journal.pntd.0006200 PLoS Neglected Tropical Diseases Q1
Artículo en revista científica The other Campylobacters: Not innocent bystanders in endemic diarrhea and dysentery in children in low-income settings François R. 2018 10.1371/journal.pntd.0006200 PLoS Neglected Tropical Diseases Q1
Artículo en revista científica Astrovirus infection and diarrhea in 8 countries Olortegui M.P. 2018 10.1542/peds.2017-1326 Pediatrics Q1
Artículo en revista científica A longitudinal study of household water, sanitation, and hygiene characteristics and environmental enteropathy markers in children less than 24 months in Iquitos, Peru Exum N.G. 2018 10.4269/ajtmh.17-0464 American Journal of Tropical Medicine and Hygiene Q1
Artículo en revista científica Causal Pathways from Enteropathogens to Environmental Enteropathy: Findings from the MAL-ED Birth Cohort Study Kosek M.N. 2017 10.1016/j.ebiom.2017.02.024 EBioMedicine Q1
Artículo en revista científica Vaccine coverage and adherence to EPI schedules in eight resource poor settings in the MAL-ED cohort study Hoest C. 2017 10.1016/j.vaccine.2016.11.075 Vaccine Q1
Artículo en revista científica Environmental enteropathy is associated with cardiometabolic risk factors in Peruvian children Lee G.O. 2017 10.1017/S2040174417000071 Journal of Developmental Origins of Health and Disease Q2
Artículo en revista científica Age and Sex Normalization of Intestinal Permeability Measures for the Improved Assessment of Enteropathy in Infancy and Early Childhood: Results from the MAL-ED Study Kosek M.N. 2017 10.1097/MPG.0000000000001610 Journal of Pediatric Gastroenterology and Nutrition Q1
Article Age and Sex Normalization of Intestinal Permeability Measures for the Improved Assessment of Enteropathy in Infancy and Early Childhood: Results From the MAL-ED Study Kosek, Margaret N. 2017 10.1097/MPG.0000000000001610 JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION Q1
Artículo en revista científica Multiple entries and exits and other complex human patterns of insecticide-Treated net use: A possible contributor to residual malaria transmission? Harvey S.A. 2017 10.1186/s12936-017-1918-5 Malaria Journal Q1
Artículo en revista científica Dynamics and trends in fecal biomarkers of gut function in children from 1-24 months in the MAL-ED study McCormick B.J.J. 2017 10.4269/ajtmh.16-0496 American Journal of Tropical Medicine and Hygiene Q1
Artículo en revista científica Infant nutritional status, feeding practices, enteropathogen exposure, socioeconomic status, and illness are associated with gut barrier function as assessed by the lactulose mannitol test in the MAL-ED birth cohort Lee G.O. 2017 10.4269/ajtmh.16-0830 American Journal of Tropical Medicine and Hygiene Q1
Artículo en revista científica Floors and Toilets: Association of Floors and Sanitation Practices with Fecal Contamination in Peruvian Amazon Peri-Urban Households Exum N.G. 2016 10.1021/acs.est.6b01283 Environmental Science & Technology Q1
Artículo en revista científica Norovirus infection and acquired immunity in 8 countries: Results from the MAL-ED study Rouhani S. 2016 10.1093/cid/ciw072 Clinical Infectious Diseases Q1
Article Norovirus Infection and Acquired Immunity in 8 Countries: Results From the MAL-ED Study Rouhani, Saba 2016 10.1093/cid/ciw072 CLINICAL INFECTIOUS DISEASES Q1
Article How multiple episodes of exclusive breastfeeding impact estimates of exclusive breastfeeding duration: report from the eight-site MAL-ED birth cohort study Ambikapathi, Ramya 2016 10.1111/mcn.12352 Maternal and Child Nutrition Q1
Artículo en revista científica How multiple episodes of exclusive breastfeeding impact estimates of exclusive breastfeeding duration: report from the eight-site MAL-ED birth cohort study Ambikapathi R. 2016 10.1111/mcn.12352 Maternal and Child Nutrition Q1
Article Early child health in an informal settlement in the Peruvian Amazon Lee, Gwenyth O. 2016 10.1186/s12914-016-0099-6 BMC International Health and Human Rights Q2
Artículo en revista científica Early child health in an informal settlement in the Peruvian Amazon Lee G.O. 2016 10.1186/s12914-016-0099-6 BMC International Health and Human Rights Q1
Artículo en revista científica Plasma tryptophan and the kynurenine-tryptophan ratio are associated with the acquisition of statural growth deficits and oral vaccine underperformance in populations with environmental enteropathy Kosek M.N. 2016 10.4269/ajtmh.16-0037 American Journal of Tropical Medicine and Hygiene Q1
Artículo en revista científica Pathogen-specific burdens of community diarrhoea in developing countries: A multisite birth cohort study (MAL-ED) Platts-Mills J.A. 2015 10.1016/S2214-109X(15)00151-5 Lancet Global Health,The Q1
Artículo en revista científica Soil-transmitted helminth infections are associated with an increase in human papillomavirus prevalence and a T-helper type 2 cytokine signature in cervical fluids Gravitt P.E. 2015 10.1093/infdis/jiv498 Journal of Infectious Diseases Q1
Artículo en revista científica Early interruption of exclusive breastfeeding: Results from the eight-country MAL-ED study Patil C.L. 2015 10.1186/S41043-015-0004-2 Journal of Health, Population and Nutrition Q2
Artículo en revista científica Determinants of caregivers use and adoption of household water chlorination: A qualitative study with peri-urban communities in the Peruvian Amazon Rothstein J.D. 2015 10.4269/ajtmh.14-0654 American Journal of Tropical Medicine and Hygiene Q1
Artículo en revista científica Postpartum depressive symptoms across time and place: Structural invariance of the Self-Reporting Questionnaire among women from the international, multi-site MAL-ED study Pendergast L.L. 2014 10.1016/j.jad.2014.05.039 Journal of Affective Disorders Q1
Artículo en revista científica Assessment of environmental enteropathy in the MAL-ED cohort study: Theoretical and analytic framework Kosek M. 2014 10.1093/cid/ciu457 Clinical Infectious Diseases Q1
Artículo en revista científica Santa Clara de Nanay: The MAL-ED cohort in Peru Yori P.P. 2014 10.1093/cid/ciu460 Clinical Infectious Diseases Q1
Artículo en revista científica Effects of shigella-, campylobacter- and ETEC-associated diarrhea on childhood growth Lee G. 2014 10.1097/INF.0000000000000351 Pediatric Infectious Disease Journal Q1
Artículo en revista científica Lactulose: Mannitol diagnostic test by HPLC and LC-MSMS platforms: Considerations for field studies of intestinal barrier function and environmental enteropathy Lee G.O. 2014 10.1097/MPG.0000000000000459 Journal of Pediatric Gastroenterology and Nutrition Q1
Artículo en revista científica An instrument for the assessment of diarrhoeal severity based on a longitudinal community-based study Lee G. 2014 10.1136/bmjopen-2014-004816 BMJ Open Q1
Artículo en revista científica Short report: A phase one safety study of Lactobacillus reuteri conducted in the peruvian amazon: Observations from the field Oberhelman R. 2014 10.4269/ajtmh.13-0639 American Journal of Tropical Medicine and Hygiene Q1
Article Short Report: A Phase One Safety Study of Lactobacillus reuteri Conducted in the Peruvian Amazon: Observations from the Field Oberhelman, Richard A. 2014 10.4269/ajtmh.13-0639 AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Q1
Artículo en revista científica Infant feeding practices in the Peruvian Amazon: Implications for programs to improve feeding Lee G. 2014 Revista Panamericana de Salud Publica/Pan American Journal of Public Health Q2
Article Hyperendemic malaria transmission in areas of occupation-related travel in the Peruvian Amazon Parker, Benjamin S. 2013 10.1186/1475-2875-12-178 MALARIA JOURNAL Q1
Artículo en revista científica Hyperendemic malaria transmission in areas of occupation-related travel in the Peruvian Amazon Parker B.S. 2013 10.1186/1475-2875-12-178 Malaria Journal Q1
Artículo en revista científica Symptomatic and Asymptomatic Campylobacter Infections Associated with Reduced Growth in Peruvian Children Lee G. 2013 10.1371/journal.pntd.0002036 PLoS Neglected Tropical Diseases Q1
Article Symptomatic and Asymptomatic Campylobacter Infections Associated with Reduced Growth in Peruvian Children Lee, Gwenyth 2013 10.1371/journal.pntd.0002036 PLoS Neglected Tropical Diseases Q1
Artículo en revista científica REG1B as a predictor of childhood stunting in Bangladesh and Peru1-3 Peterson K.M. 2013 10.3945/ajcn.112.048306 American Journal of Clinical Nutrition Q1
Artículo en revista científica Trials of improved practices (TIPs): A strategy for making long-lasting nets last longer? Harvey S.A. 2013 10.4269/ajtmh.12-0641 American Journal of Tropical Medicine and Hygiene Q1
Artículo en revista científica Fecal markers of intestinal inflammation and permeability associated with the subsequent acquisition of linear growth deficits in infants Kosek M. 2013 10.4269/ajtmh.2012.12-0549 American Journal of Tropical Medicine and Hygiene Q1
Artículo en revista científica Socio-demographics and the development of malaria elimination strategies in the low transmission setting Chuquiyauri R. 2012 10.1016/j.actatropica.2011.11.003 Acta Tropica Q1
Article Socio-demographics and the development of malaria elimination strategies in the low transmission setting Chuquiyauri, Raul 2012 10.1016/j.actatropica.2011.11.003 ACTA TROPICA Q1
Artículo en revista científica Comparative effects of vivax malaria, fever and diarrhoea on child growth Lee G. 2012 10.1093/ije/dyr190 International Journal of Epidemiology Q1
Artículo en revista científica Facilitated molecular typing of shigella isolates using ERIC-PCR Kosek M. 2012 10.4269/ajtmh.2012.11-0671 American Journal of Tropical Medicine and Hygiene Q1
Artículo en revista científica Socio-demographics and the development of malaria elimination strategies in the low transmission setting. Chuquiyauri R 2012 Acta tropica No Aplica
Review Shigellosis update: Advancing antibiotic resistance, investment empowered vaccine development, and green bananas Kosek M. 2010 10.1097/QCO.0b013e32833da204 Current Opinion in Infectious Diseases Q1
Artículo en revista científica Norovirus highly prevalent cause of endemic acute diarrhea in children in the peruvian amazon Yori P.P. 2009 10.1097/INF.0b013e3181a24730 Pediatric Infectious Disease Journal Q1
Artículo en revista científica Epidemiology of highly endemic multiply antibiotic-resistant shigellosis in children in the peruvian amazon Kosek M. 2008 10.1542/peds.2008-0458 Pediatrics Q1
Artículo en revista científica The whole world will be able to see us: Determining the characteristics of a culturally appropriate bed net among mestizo communities of the Peruvian Amazon Harvey S.A. 2008 10.4269/ajtmh.2008.79.834 American Journal of Tropical Medicine and Hygiene Q1
Artículo en revista científica Seroepidemiology of strongyloidiasis in the Peruvian Amazon Yori P.P. 2006 10.4269/ajtmh.2006.74.97 American Journal of Tropical Medicine and Hygiene Q1

* Sólo se presentan los cuartiles para la producción tipo artículos y review.

** Cuartil no disponible para el año de la publicación.

*** La revista no tiene cuartil en el año de la publicación.


Otras Producciones

Tipo de Producción Título Año de Producción Título de la fuente

Proyectos de Investigación

Tipo Proyecto Título Descripción Institución Fecha de Inicio Fecha Fin Inv. Principal Área OCDE

Proyectos importados de ORCID

Tipo de financiamiento Título Descripción Institución Fecha de Inicio Fecha de Fin
GRANT L. reuteri for Pediatric Diarrhea in Peru: Growth, Enteropathy, and Microbiota DESCRIPTION (provided by applicant): Despite the fact that the great majority of cases of diarrhea occur in children living in impoverished settings, the evidence for the safety and efficacy of probiotics is principally derived from the U.S. and Europe. The long term goal is to improve quality of evidence regarding the safety, efficacy, and mechanism of action of probiotics for the treatment of diarrhea in early childhood in a population living in extreme poverty, where diarrhea, enteropathy, and stunting are common, so that evidenced-based probiotic strategies may be designed. Approach: The work will be conducted through first performing a Phase 1 study in infants and then proceeding to conduct a Phase 2 Clinical Trial in a birth cohort in Peru. The successful completion of these studies will evaluate safety in this population and yield information on the efficacy of L. reuteri DSM 17938 for all cause diarrhea and diarrhea caused by Norovirus, Campylobacter, Giardia, and Enteroggerative E. coli. Innovative aspects include a design that allows for the evaluation of the cumulative effect of the administration of the product strain on each incident episode over the first two years of life on the cumulative burden of disease and linear growth. Integrated measures including intestinal inflammation, permeability, and systemic inflammation will be complemented by studies of the gut microbiome on sample subsets to contribute important new information on the changes in the host physiology and microbiota that can be associated with treatment with treatment with L. reuteri DSM 17938. The research team is composed of scientists with diverse backgrounds and extensive experience in clinical trials, longitudinal field studies with intensive surveillance, and enteric diseases in Peu that is well positioned to carry out the regulatory, field, and basic science project components described in this proposal. National Institute of Diabetes and Digestive and Kidney Diseases Setiembre 2014 Agosto 2020
GRANT Enabling Infectious Disease Research Capacity in the Peruvian Amazon 7. Project Summary/Abstract Peru is rapidly increasing in stature in public health research, and many successful Peruvian-US research teams have expanded research capacity through training grants based in major universities in Lima. Many of these partnerships have satellite activities to study tropical diseases in Iquitos, the major city in the Peruvian Amazon, but these research and capacity building activities have largely bypassed academic institutions in Iquitos. This D43 training grant is specifically designed to address and correct this disparity, offering a collaborative research training program in partnership with the Universidad Nacional de la Amazonia Peruana (UNAP; National University of the Peruvian Amazon), the largest health education institution in the region. Our goal is to expand the local workforce of highly trained professionals with public health and infectious diseases research skills, which we propose to achieve by forming a collaborative Master?s degree program based at UNAP for six competitively selected health professionals, leading to a Master?s degree in Public Health from UNAP and a Certificate in International Research in Infectious Diseases from the consortium training program. This intensive, mentored training program with both north-south and south-south training components will be led by faculty from four collaborating institutions (UNAP, Universidad Peruana Cayetano Heredia [the leading biomedical research university in Peru, located in Lima], Tulane, and Johns Hopkins). The program will be fully integrated with the standard Peruvian training program for health professionals, allowing for trainees to complete their academic and field service requirements while benefiting from the intensive training during programed gap periods and during the standard two-year MPH program at UNAP, while adding less than six months to their total training period. The majority of the training will be conducted locally at UNAP through training modules and online components, although three months of the initial training period will be carried out at Johns Hopkins as part of the Summer Institute of Epidemiology and Biostatistics and the Summer Institute of Tropical Medicine and Public Health. We will supplement the two-year MPH program at UNAP with complementary, short-term training modules led by Tulane, Johns Hopkins, and UPCH faculty that will be open to all MPH students in the UNAP program, expanding the impact of the training program to approximately 80 additional trainees. Working closely with UNAP faculty, we will integrate new program content into the existing MPH curriculum, providing sustainable, ongoing benefits for future UNAP MPH classes. MPH trainees will conclude their training by taking a leading role in writing and assembling a CONCYTEC proposal (Consejo Nacional de Ciencia, Tecnología, e Innovación Tecnológica [Nacional Counsel on Science, Technology, and Technological Innovation], the premier scientific funding agency in Peru) under the direction of a mentoring team. One-month short courses during Years 2-5 for training community field workers and laboratory support staff will also be offered, expanding the pool of research program support staff in Iquitos. Fogarty International Center Abril 2018 Febrero 2023
GRANT Epidemiology of Shigellosis in the Peruvian Amazon DESCRIPTION (provided by applicant): Shigellosis is the principal cause of clinical dysentery and a frequent cause of morbidity and mortality in children in impoverished regions. Due to the rapid spread of multiple antibiotic resistant strains and the lack of an available vaccine the morbidity and mortality from shigellosis is likely to increase worldwide. In the initial period of IRSDA support the determination of age-specific incidence rates of shigellosis, risk factors for disease development, antibiotic resistance profiles and regional serotype data to define the burden of drug resistant Shigella and serotype distribution of isolates in a highly endemic area was completed. ERIC-PCR was compared to the gold standard PFGE for the molecular typing of a subset of isolates and was found to be have a nearly equal discriminatory index to PFGE and was simpler, faster, and more affordable therefore more appropriate for use in endemic areas. Isolates from sentinel children under longitudinal surveillance and their contacts studied in a nested case control study to determine the mode of interfamilial spread was limited by the low yield of cultures. The identification of Shigella nearly exclusively by PCR in environmental sources including flies, drinking water, surface waters, and hand washings necessitate the identification and evaluation of a typing method that does not require primary isolation by culture to fully understand the transmission dynamics of shigellosis. The present supplemental application will address the relevance of these sources using a combined approach including PCR detection, epidemiologic analysis of the risk of proximity to these PCR positive but culture negative sources and a space-time analysis of sources of infection in order to optimally understand the ecology and transmission dynamics of this important pathogen. The collaborative research group that is assembled to conduct this study is an established international group of epidemiologists, physicians, biostatisticians, and molecular biologists with a proven track record in the training of junior scientists in an international setting. The proposed project will further strengthen these international research ties in the process of the continued training of a promising physician-scientist. Fogarty International Center Setiembre 2001 Agosto 2008
GRANT Genomic features of host adaptation of Campylobacter in low-income settings ABSTRACT There is strong epidemiologic evidence of human adaption of the zoonotic pathogen Campylobacter. However, the genomic features of such adaptation have not been systematically evaluated. The overall objective of this project is to identify specific genomic features of Campylobacter that are associated with adaptation to the human host with the long-term goal of applying this knowledge to global reference databases to inform host attribution and guide improved disease control measures to reduce the global burden of Campylobacter disease in humans. Our central hypothesis is that in highly endemic settings, long-term exposure has allowed adaptation to the human host, as opposed to the transient infection epidemiology we usually observe with Campylobacter. Previous evidence of human adaption has been previously suggested by prolonged carriage in immunosuppressed patients and that certain Campylobacter lineages associated with human disease and chronic sequelae such as GBS, are rarely found outside the human host. We have identified these observations in two longitudinal cohort studies in the Peruvian Amazon that cumulatively comprise over 1400 child-years of surveillance, 20,000 stool samples and 850 Campylobacter isolates. Specifically, we evidence a) persistent Campylobacter infection and carriage in over 70% of children with complete 0 to 24-month follow-up, b) high-level of C. jejuni strain diversity derived from humans compared to the global collection of clinical genomes, c) high proportion of strains described exclusively in human hosts (such ST-403, ST2802 and ST- 2993), as compared to the global reference collection and d) considerable reduced genome size of human derived C. jejuni genomes compared to the global reference collection. In order to test our hypothesis, we will 1) Identify genomic features of persistent Campylobacter infections in humans, and 2) Determine if spatiotemporally clustered infections represent human to human transmission. The proposed project will unite a highly complementary group of accomplished researchers with expertise in epidemiology, evolutionary biology, Campylobacter genomics, and bioinformatics to inform strategic and targeted disease control interventions for Campylobacter control in an area with one of the highest documented rates of human MDR Campylobacter infection. [The project is innovative in the way it applies microbial GWAS methods to capitalize on an exceptional strain bank derived from well-defined longitudinal cohort studies to efficiently identify host adaptation.] [High quality evidence of human host adaptation generated by this study would be paradigm shifting to strategies used to control Campylobacter and would likely to alter the clinical management of Campylobacter enteritis.] National Institute of Allergy and Infectious Diseases Mayo 2022 Abril 2024
GRANT Genomic Epidemiology of Campylobacter to Improve Disease Control in Low and Middle Income Countries ABSTRACT Campylobacter is among the principal causes of bacterial enteritis worldwide and the progressive development of antimicrobial resistance among global isolates, particularly in low and middle income countries, has led the CDC to list drug-resistant Campylobacter at the top of its list of serious threats in 2019. In the past decade in Europe major investments in genomic epidemiology have informed successful interventions to decrease rates of human infection and sequelae such as Guillan-Barre syndrome. Despite clear evidence that Campylobacter is a principal cause of enteritis in the developing world, advanced approaches in source attribution have not been employed to identify the principal sources of infection causing disease in humans, or to identify the sources of human infections resistant to both fluoroquinolones and azithromycin (MDR Campylobacter), despite their documented high incidence. The limited genomic study of Campylobacter done in low and middle income countries demonstrates important differences in the genomes of isolates from both humans and zoonotic sources, indicating that transmission dynamics differ in these settings compared to that seen in high income countries. The current deficit in accurate quantitative source attribution to zoonotic source populations where most infections occur is a critical knowledge gap in the global control of Campylobacter infections. The objective of this project is to inform targeted disease control measures to reduce the impact of campylobacteriosis and human MDR Campylobacter in low and middle income countries. Our central hypothesis is that industrially produced meat products are the principal source of campyobacteriosis and MDR Campylobacter in humans in this population. In order to test our central hypothesis we will 1) identify host segregating features of Campylobacter from zoonotic sources in Peru; 2) characterize genomes of Campylobacter strains that cause disease in humans, evaluate the risk of household peron-to-person transmission and identify microbial genomic features associated with persistent asymptomatic human carriage and 3) estimate the burden of campylobacteriosis and human MDR infections attributable to domestic and industrially derived zoonotic sources. The proposed project will unite a highly complementary group of accomplished researchers with expertise in epidemiology, Campylobacter genomics, bioinformatics and microbial ecology to inform strategic and targeted disease control interventions for Campylobacter control in an area with one of the highest documented rates of human MDR Campylobacter infection. The project is innovative in its approach to link characterized human cases and zoonotic reservoirs in a high burden LMIC setting to local, regional, and global reference genomes to create robust evidence to drive policy and practice to improve the control of campylobacteriosis and the diminish the geographic expansion of MDR Campylobacter. National Institute of Allergy and Infectious Diseases Marzo 2021 Febrero 2026
GRANT GH20-005, Conducting Integrated Infectious Disease and Public Health Research in Peru PROJECT SUMMARY: The proposed application aims to overcome diagnostic barriers in the etiologic diagnosis of endemic and epidemic causes of acute febrile illness (AFI) by moving efficient state of the art diagnostics to an area of high endemicity. The long-term goal of this research is to understand the etiology of AFI across diverse contexts in South America and contribute to global strategies that improve etiology-specific disease estimates to inform public health practice and policy. The central hypothesis is that the technology transfer and implementation of improved diagnostics will enhance regional diagnostic capacity, epidemic responsiveness, and translation of research findings to practice maximizing the public health impact of research findings. The rationale for the research is that the documented feasibility of this approach will enable a full and appropriate evaluation for uptake by regional and national stakeholders. The goals of the research will be achieved through the execution of three specific aims: 1) Establish stable year round acute febrile illness surveillance using the TaqMan array card, which simultaneously detects over 30 pathogens of AFI across three epidemiologic contexts in Loreto, Peru; urban, riverine with extensive sylvatic exposure, and agricultural riverine context along the three country border (Peru, Brazil, and Colombia) in order to capture the diversity of pathogens causing AFI in Peru over a four year period; 2) Integrate this diagnostic platform into the regional outbreak response to determine the etiology of epidemics of acute febrile illness and validating improved storage and transport procedures; and 3) Develop and evaluate novel serodiagnostic chip to enable single platform serologic assessment and downstream point of care tests and focused diagnostics for pathogens of high prevalence and importance. The global control of emerging infectious diseases will be improved only as the areas that are not reached and included effectively in surveillance shrink and the proposed project attempts to implement a strategy to make all populations reachable to the improved diagnostics. The complexity of current diagnostic strategies is a critical barrier to the timely regional ascertainment of the etiology of most cases of acute febrile illnesses and this has important regional and global public health implications as undiagnosed AFI allows for the widespread dissemination of emerging diseases as effective disease control measures are based on accurate etiologic assessment. The plan is innovative because of the meaningful integration of highly select local researchers, educators, trainees, and policymakers. The implementation of the research strategy will be significant because it is expected to contribute to the accuracy of etiologic assessment of endemic and epidemic etiologies of AFI in an area of documented diversity of vector-borne and zoonotic agents and serve as a model for enabling local diagnostic and reporting capacity in South America. Centers for Disease Control and Prevention Setiembre 2020 Setiembre 2023

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